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Model of OMV biogenesis. In the presence of a specific glycan (1), Bacteroides induces specific PULs (2). Glycosyl-hydrolases containing the LES signal are transported to the OM and exposed to the cell surface. OMV-targeted lipoproteins cluster at defined foci in the OM (3), where they are formed (4) by an unknown mechanism. OMVs diffuse and hydrolyze glycans that can be imported by the OMV-producing bacteria, as well as other commensals and pathogens (5). Created with Biorender.
