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. 2023 Jun 27;31(4):437–448. doi: 10.32604/or.2023.029924

Table 1. Partially recruited or completed clinical trials of neoantigen combination therapy.

Platform Phase Cancer type Combinnd therapies ClinicalTrial.gov identifier
DC vaccine II Hepatocellular Cancer Colorectal Cancer Nivolumab NCT04912765
DNA vaccine I/II Hepatocellular Cancer NO-9012 Pembrolizumab NCT04251117
II Small Cell Lung Cancer Durvalumab NCT04397003
mRNA vaccine / Gastric Cancer Esophageal Cancer Liver Cancer PD-1/L1 NCT05192460
SLP vaccine I Pancreatic Cancer Metastatic Colorectal Cancer Metastatic Retifanlimab NCT04799431
I/II Melanoma Ocular Melanoma Uveal Melanoma 6MHP PolyICLC CDX-1140 NCT04364230
I Squamous Cell Lung Cancer Squamous Non-small Cell Lung Cancer Squamous Cell Carcinoma of Head and Neck Pembrolizumab NCT04266730
TIL I Epithelial Tumors NMA-LD Regimen Interleukin-2 NCT05141474
TCR-T II Endocrine Tumors Non-Small Cell Lung Cancer Ovarian Cancer Breast Cancer Gastrointestinal/Genitourinary Cancers Neuroendocrine Tumors Multiple Myeloma Cyclophosphamide Fludarabine Aldesleukin Pembrolizumab NCT03412877
II Non-Small Cell Lung Cancer Breast Cancer Gastrointestinal/Genitourinary Cancers Ovarian Cancer Fludarabine Cyclophosphamide Aldesleukin NCT04102436
CAR-T I Glioblastoma Pembrolizumab NCT03726515