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Pathway‐centric risk classification for patients with colorectal liver metastases. (A) Grades assigned according to APC, TP53, RAS/BRAF, and SMAD4 mutation status. (B) Overall survival by grade. (C) Overall survival by grade in a validation cohort from Memorial Sloan Kettering Cancer Center. (Adapted from Kawaguchi et al 33 with permission.)
