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. 2023 Jun 20;10:1064949. doi: 10.3389/fcvm.2023.1064949

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© 2023 Liu, Yang, Su, Zhang and Xing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of embryonic coronary artery development: 1. Venous sinus cells must first differentiate into pre-arterial cells before participating in coronary artery formation 2. Prdm6 promotes cardiac neural crest cells to differentiate into pericytes through epithelial-mesenchymal transformation by upregulating the expression level of WNT1. Next, pericytes differentiate into coronary smooth muscle cells under the activation of NOTCH3 signal to participate in coronary artery formation 3. Endocardial cells involved in coronary formation during embryonic development.