Table 1.
Characteristics of patients who underwent hepatectomy for neuroendocrine tumor liver metastasesa
| All patients (n = 546) | Small intestine (n = 279) | Pancreas (n = 194) | Other sites (n = 73) | p Value | |
|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | ||
| Median age: years (IQR) | 59 (50–66) | 61 (53–69) | 57 (48–64) | 55 (48–65) | < 0.001 |
| Sex | |||||
| Male | 280 (51) | 143 (51) | 104 (54) | 33 (45) | 0.47 |
| Female | 266 (49) | 136 (49) | 90 (46) | 40 (55) | |
| Functional tumor | |||||
| No | 345 (63) | 130 (47) | 161 (83) | 54 (74) | < 0.001 |
| Yes | 201 (37) | 149 (53) | 33 (17) | 19 (26) | |
| Ki-67 index (%)b | |||||
| < 3 | 69 (29) | 50 (44) | 12 (13) | 7 (26) | < 0.001 |
| 3–20 | 125 (53) | 53 (46) | 59 (63) | 13 (48) | |
| > 20 | 41 (17) | 12 (10) | 22 (24) | 7 (26) | |
| No. of liver lesions | |||||
| 1–3 | 138 (25) | 62 (22) | 51 (26) | 25 (34) | 0.030 |
| 4–9 | 126 (23) | 56 (20) | 50 (26) | 20 (27) | |
| ≥ 10 | 282 (52) | 161 (58) | 93 (48) | 28 (38) | |
| Size of largest lesion | |||||
| Median: mm (IQR) | 42 (21–70) | 40 (20–70) | 38 (20–65) | 58 (30–87) | 0.028 |
| Extrahepatic distant metastases | |||||
| No | 456 (84) | 211 (76) | 179 (92) | 66 (90) | < 0.001 |
| Yes | 90 (16) | 68 (24) | 15 (7.7) | 7 (9.6) | |
| Extent of cytoreduction | |||||
| Complete cytoreduction | 410 (75) | 209 (75) | 146 (75) | 55 (75) | 0.95 |
| Incomplete debulking (> 90%) | 110 (20) | 56 (20) | 38 (20) | 16 (22) | |
| Incomplete debulking (< 90%) | 26 (4.8) | 14 (5.0) | 10 (5.2) | 2 (2.7) | |
IQR, interquartile range
aCategorical variables are presented as number (%) and continuous variables as median (IQR)
bPatients with missing Ki-67 values (n = 307) were excluded from the respective univariate analysis