Table 4.

Uni- and multivariable Cox regression analysis of factors associated with progression-free survival from hepatectomy^a

	Univariate analysis		Multivariable analysis
	HR (95% CI)	p Value	HR (95% CI)	p Value
Age at hepatectomy
Increase per year	0.98 (0.97–0.99)	< 0.001	0.98 (0.98–0.99)	< 0.001
Sex
Male	1.00 (reference)
Female	1.01 (0.83–1.22)	0.95
Primary tumor site
Small intestine	1.00 (reference)		1.00 (reference)
Pancreas	1.75 (1.43–2.16)	< 0.001	1.80 (1.40–2.32)	< 0.001
All other sites	1.02 (0.74–1.39)	0.92	1.13 (0.81–1.59)	0.48
Functional tumor
No	1.00 (reference)
Yes	1.03 (0.85–1.26)	0.76
Ki-67 Index (%)
< 3	1.00 (reference)		1.00 (reference)
3–20	1.47 (0.99–2.18)	0.06	1.25 (0.83–1.88)	0.28
> 20	2.20 (1.35–3.59)	0.002	1.73 (1.04–2.89)	0.034
No. of metastases
1–3 Lesions	1.00 (reference)		1.00 (reference)
4–9 Lesions	1.81 (1.35–2.41)	< 0.001	1.74 (1.29–2.36)	< 0.001
≥ 10 Lesions	1.94 (1.51–2.49)	< 0.001	1.64 (1.23–2.19)	< 0.001
Size of largest metastasis
Increase per cm	1.04 (1.02–1.07)	< 0.001	1.04 (1.01–1.06)	0.007
Extrahepatic distant metastases
No	1.00 (reference)		1.00 (reference)
Yes	1.25 (0.97–1.61)	0.09	1.22 (0.92–1.62)	0.17
Extent of cytoreduction
Complete cytoreduction	1.00 (reference)		1.00 (reference)
Incomplete (>90%)	1.78 (1.41–2.25)	< 0.001	1.55 (1.19–2.01)	0.001
Incomplete (90%)	1.78 (1.14–2.78)	0.011	1.51 (0.94–2.41)	0.09

HR, hazard ratio; CI, confidence interval

^aVariables with p < 0.20 in the univariate analysis were included in the multivariable model. Data are presented after multiple imputation for Ki-67