Table 3.
Univariable and Multivariable analysis for recurrent disease
| Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|
| HR* | p-value | HR* | 95% CI** | p-value | |
| Gender | |||||
| Female | Reference | ||||
| Male | 0.943 | 0.802 | |||
| Age in years at primary diagnosis | 0.98 | 0.014 | 0.98 | 0.96-1.00 | 0.074 |
| Size | |||||
| <2cm | Reference | Reference | |||
| >2cm | 2,505 | 0.025 | 2.52 | 0.97-6.54 | 0.058 |
| Site | |||||
| Head and Neck | Reference | Reference | |||
| Extremity | 2,015 | 0.003 | 1,714 | 0.75-3.93 | 0.204 |
| Trunk | 0.623 | 0.509 | 0.392 | 0.08-2.06 | 0.269 |
| Resection margin | |||||
| R0 | Reference | ||||
| R1 | 0.803 | 0.434 | |||
| Differentiation grade primary tumor | |||||
| Well | Reference | ||||
| Intermediate | 1,358 | 0.397 | |||
| Poor | 1.5 | 0.285 | |||
| Tickness primary tumor | |||||
| <6mm | Reference | Reference | |||
| >6mm | 2,339 | 0.063 | 2,462 | 0.90-6.72 | 0.08 |
| Perineural invasion primary tumor | |||||
| No | Reference | ||||
| Yes | 1,296 | 0.553 | |||
| Immunosupression | |||||
| No | Reference | Reference | |||
| Yes | 1,815 | 0.042 | 2,399 | 0.96-5.98 | 0.061 |
| PORT of metastases | |||||
| No | Reference | Reference | |||
| Yes | 0.608 | 0.018 | 1,053 | 0.56-1.98 | 0.322 |
| Lymph node extracapsular spread | |||||
| No | Reference | ||||
| Yes | 0.978 | 0.932 | |||
| Differantiation grade lymph node | |||||
| Well | Reference | ||||
| Moderate | 0.762 | 0.522 | |||
| Poor | 1,702 | 0.167 | |||
| Size largest lymph node | 1.01 | 0.044 | 1,008 | 0.99-1.02 | 0.213 |
| Positive lymph nodes | |||||
| 1 | Reference | ||||
| >1 | 2,365 | 0.002 | 2,147 | 1.17-3.94 | 0.014 |
*HR= Hazard ration. ** CI = confidence interval