Table 2.

Predictors for R0 resection in 2955 patients after pancreatoduodenectomy for pancreatic cancer

	According to 1 mm tumor clearance (main study definition)
	Univariable analysis	P-value	Multivariable analysisa	P-value
	OR (95% CI)		OR (95% CI)
Age	0.99 (0.98–0.99)	0.003	0.99 (0.98–0.99)	0.008
Female	1.04 (0.89–1.20)	0.604
Neoadjuvant chemo(radio)therapy	1.29 (0.98–1.71)	0.075
T stageb
1	Reference		Reference
2	0.37 (0.27–0.48)	< 0.001	0.49 (0.37–0.64)	< 0.001
3	0.36 (0.28–0.47)	< 0.001	0.35 (0.26–0.47)	< 0.001
4	0.19 (0.13–0.29)	< 0.001	0.23 (0.14–0.35)	< 0.001
LNR	0.22 (0.15–0.31)	< 0.001	0.29 (0.20–0.42)	< 0.001
PD performed in high-volume center (≥ 40 PD/year)	0.87 (0.76–1.01)	0.077
Completeness of pathology reportc	0.77 (0.70–0.84)	< 0.001	0.76 (0.69–0.83)	< 0.001

Bold numbers in univariable analysis indicate variables that were entered in multivariable analysis. Bold numbers in multivariable analysis indicate statistical significance (P < 0.05). OR odds ratio, LNR lymph node ratio, PD pancreatoduodenectomy

^aMultivariable analysis after backward step selection in 2876 patients (62 deleted due to missing values)

^bif pT stage was unavailable, cT stage was used

^cscore between 0–6 based on the following variables: histological diagnosis, origin of the tumor, resection margin, extent of invasion, LNR, and tumor size