Table 3.
Predictors for overall survival in 2955 patients after pancreatoduodenectomy for pancreatic cancer
| According to 1 mm tumor clearance (main study definition) | ||||
|---|---|---|---|---|
| Univariable analysis | P-value | Multivariable analysisa | P-value | |
| HR (95% CI) | HR (95% CI) | |||
| R0 resectionb | 0.68 (0.63–0.74) | < 0.001 | 0.72 (0.66–0.79) | < 0.001 |
| Age | 1.01 (1.01–1.02) | < 0.001 | 1.00 (1.00–1.01) | 0.047 |
| Female | 0.98 (0.90–1.06) | 0.548 | ||
| Chemo(radio)therapy | ||||
| None | Reference | Reference | ||
| Neoadjuvant | 0.81 (0.62–1.05) | 0.104 | 1.03 (0.79–1.35) | 0.81 |
| Adjuvant | 0.67 (0.61–0.73) | < 0.001 | 0.61 (0.56–0.67) | < 0.001 |
| Both | 0.52 (0.41–0.67) | < 0.001 | 0.73 (0.57–0.95) | 0.017 |
| T stagec | ||||
| 1 | Reference | Reference | ||
| 2 | 1.76 (1.50–2.07) | < 0.001 | 1.52 (1.29–1.79) | < 0.001 |
| 3 | 2.24 (1.89–2.66) | < 0.001 | 1.82 (1.52–2.17) | < 0.001 |
| 4 | 2.35 (1.87–2.95) | < 0.001 | 1.59 (1.25–2.01) | < 0.001 |
| LNR | 4.66 (3.93–5.54) | < 0.001 | 4.09 (3.41–4.90) | < 0.001 |
| PD performed in center with volume ≥ 40 PD/year | 0.81 (0.74–0.87) | < 0.001 | 0.84 (0.77–0.91) | < 0.001 |
| Year of resection | 0.98 (0.63–0.74) | 0.006 | ||
Bold numbers in univariable analysis indicates variables that were entered in multivariable analysis. Bold numbers in multivariable analysis indicates statistical significance (P < 0.05). OR: Odds ratio. LNR: lymph node ratio. PD: pancreatoduodenectomy
aMultivariable analysis after backward step selection in 2898 patients (57 deleted due to missing values
bFollowing the definitions above/on top of the table
cIf pT stage was unavailable, cT stage was used