Fig. 1.

CSPH can be ruled-out or ruled-in by assessing LSM (by VCTE) and PLT and applying the Baveno VII criteria. Patients within the grey zone of the Baveno VII criteria may be reclassified by von Willebrand factor (VWF) to platelet count (PLT) ratio (VITRO) or spleen stiffness measurement SSM (by VCTE). Patients with inconclusive non-invasive findings should be evaluated by hepatic venous pressure gradient (HVPG)-measurement and/or endoscopy for the presence of clinically significant portal hypertension (CSPH) and varices (which are confirmative of CSPH), respectively. Alternative (i.e., non-VCTE-based) strategies, should limited to settings where VCTE is not available