Table 2.

Diagnostic criteria for ACLF and grading

Organ system	Variable	Dysfunction	Failure
Liver	Bilirubin (mg/dL)	≥ 6.0 to < 12	≥ 12
Kidney	Creatinine (mg/dL)	> 1.5 to < 2.0	≥ 2.0 or use of RRT
Brain	HE West Haven Grade	I–II	III–IV or intubation for HE
Coagulation	INR	≥ 2.0 to < 2.5	≥ 2.5
Circulation	MAP (mm Hg)	< 70	Use of Vasopressors (not considering Terlipressin)
Lung	PaO2/FiO2 SpO2/FiO2	201 to 300 215 to 357	≤ 200 ≤ 214 or mechanical ventilation
ACLF grading
–	Grade 1	1a—Single renal failure (sCre ≥ 2.0 mg/dL) 1b—Isolated liver or coagulation failure combined with either (i) renal dysfunction (sCre 1.5 to < 2.0 mg/dL) or (ii) brain dysfunction (HE I–II)
	Grade 2	2 organ failures
	Grade 3	3a—3 organ failures 3b—≥ 4 organ failures