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. 2023 Jul 4;14:3952. doi: 10.1038/s41467-023-39704-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The indicated viruses were inoculated into VeroE6/TMPRSS2 cells at an MOI of 0.001. After 8, 16, 24, 32, 40, 48, 56, and 72 h incubation in the absence (a) or presence (b) of 20 μM nirmatrelvir, virus titers were determined by use of plaque assays on VeroE6/TMPRSS2 cells. The data shown are mean virus titers ± standard deviation (n = 3 independent experiments). Data were analyzed by using a two-way ANOVA followed by Tukey’s multiple comparisons.