Figure 3.

Schematic diagram summarizing some of the main results and their interpretations. They are integrated into a broader bottom-up perspective representing mechanistic convergence from genes to diagnoses. Rare genetic variants (bottom level) converge on a limited set of transcriptomic modules. The latter may converge on brain alterations (e.g. thalamo-somatomotor overconnectivity, middle-level). Brain alterations may underly differences in cognitive and clinical dimensions altered across several diagnoses (e.g. ASD and SZ, top-level). We showed convergence on sensory-motor FC networks and a pleiotropic effect of sensory-motor dimensions across psychiatric diagnoses.