Table 1.
Index SNPs of novel loci associated with BMD.
| rsID | CHR | BP | Location | Gene | A1 | EAF | SK-Effect | P | eBMD-Effect | P |
|---|---|---|---|---|---|---|---|---|---|---|
| rs12107945 | 3 | 147163978 | 3q24 | ZIC1 | A | 0.30 | −0.049 | 1.37E-10 | −2.3E-4 | 0.73 |
| rs11993347 | 8 | 103919090 | 8q22.3 | ATP6V1C1/AZIN1 | T | 0.77 | 0.059 | 2.67E-12 | 0.004 | 0.025 |
| rs61863293* | 10 | 132252499 | 10q26.3 | GLRX3 | A | 0.35 | −0.046 | 2.80E-08 | 0.002 | 0.16 |
| rs71378928 | 17 | 66453305 | 17q24.2 | PRKAR1A/WIPI1 | C | 0.23 | −0.050 | 2.67E-09 | 0.003 | 0.24 |
*Values for eBMD are reported for rs61861957 (r2 = 0.914). Gene names are shown in italic font.
Variants associated with SK-BMD in the meta-analysis (N = 43,800) that map outside + /− 500 Kb of known index SNPs of genetic associations with different bone traits. Genomic coordinates are on build 37 of the human genome. Effect sizes and allele frequencies (EAF) are reported for the A1 allele. eBMD statistics are reported from Morris et al.4 meta-analysis comprising 426,824 individuals.