Figure 2.

Miami plot of genome and transcriptome-wide associations with migraine

The top figure is the TWAS Manhattan plot for the tissue-specific analysis using information from all 53 tissues. Each point corresponds with an association test between predicted gene expression with migraine risk. The bottom figure is the Manhattan plot corresponding with the GWAS meta-analysis combining results from GERA and the UK Biobank, where each dot corresponds with an association test for an SNP with migraine risk. Blue labels indicate colocalized eQTL and GWAS signals in tissue-specific models. Red lines indicate the Bonferroni significance levels for GWAS (p < 5 × 10⁻⁸) and tissue-specific TWAS (p < 1.92 × 10⁻⁷), respectively.