Table 2.
Multi-tissue omnibus test of migraine identified 40 genes meeting criteria for statistical significance
| Gene | NUM.REF | MIN.TWAS.P | NUM.REF.PRUNED | OMNIBUS.P | CHR | P0 | P1 |
|---|---|---|---|---|---|---|---|
| AC007405.2 | 6 | 3.98 × 10−6 | 6 | 1.16 × 10−6 | 2 | 171568961 | 171571077 |
| ANKDD1B | 20 | 3.50 × 10−6 | 18 | 2.60 × 10−12 | 5 | 74907284 | 74967671 |
| ARL3 | 18 | 4.75 × 10−6 | 17 | 8.79 × 10−62 | 10 | 104433488 | 104474164 |
| ATF5a | 20 | 2.79 × 10−6 | 20 | 1.02 × 10−19 | 19 | 50433021 | 50437192 |
| C12orf4 | 3 | 2.75 × 10−13 | 3 | 2.97 × 10−15 | 12 | 4596894 | 4647674 |
| CCND2 | 5 | 2.23 × 10−13 | 5 | 5.78 × 10−11 | 12 | 4382938 | 4414516 |
| CNNM2 | 5 | 1.63 × 10−6 | 5 | 2.70 × 10−7 | 10 | 104678050 | 104849978 |
| CNTNAP1a | 25 | 2.44 × 10−7 | 16 | 1.81 × 10−91 | 17 | 40835936 | 40851832 |
| DLST | 5 | 7.46 × 10−7 | 5 | 5.41 × 10−8 | 14 | 75348593 | 75370450 |
| FAM189A2 | 12 | 8.94 × 10−8 | 12 | 2.34 × 10−7 | 9 | 71939488 | 72007371 |
| FXN | 6 | 5.61 × 10−10 | 6 | 1.31 × 10−23 | 9 | 71650175 | 71715094 |
| INA | 4 | 4.52 × 10−6 | 4 | 2.73 × 10−6 | 10 | 105036920 | 105050108 |
| INHBE | 3 | 7.28 × 10−7 | 3 | 2.76 × 10−6 | 12 | 57846106 | 57853063 |
| INPP5B | 49 | 2.36 × 10−6 | 31 | 2.74 × 10−31 | 1 | 38326764 | 38412729 |
| KTN1-AS1a | 19 | 4.08 × 10−8 | 15 | 2.26 × 10−42 | 14 | 55965996 | 56046828 |
| LRP1 | 4 | 1.22 × 10−27 | 4 | 1.90 × 10−30 | 12 | 57522276 | 57607134 |
| MLXIPL | 22 | 2.13 × 10−6 | 18 | 6.29 × 10−91 | 7 | 73007524 | 73038873 |
| MRVI1 | 25 | 1.01 × 10−11 | 24 | 2.10 × 10−10 | 11 | 10594638 | 10715535 |
| MSL3P1 | 27 | 5.30 × 10−6 | 24 | 3.64 × 10−22 | 2 | 234774083 | 234777090 |
| MTMR3 | 48 | 2.35 × 10−6 | 32 | 1.41 × 10−151 | 22 | 30279144 | 30426855 |
| NEIL1a | 19 | 6.00 × 10−6 | 18 | 1.63 × 10−13 | 15 | 75639296 | 75647550 |
| NEK4a | 30 | 7.62 × 10−6 | 14 | 7.46 × 10−8 | 3 | 52744800 | 52804965 |
| NNTa | 31 | 6.62 × 10−6 | 28 | 4.28 × 10−50 | 5 | 43602794 | 43707507 |
| NT5C2 | 16 | 4.68 × 10−7 | 15 | 2.45 × 10−112 | 10 | 104850368 | 104953056 |
| NXPH4 | 3 | 7.86 × 10−10 | 3 | 3.66 × 10−10 | 12 | 57610578 | 57620232 |
| PHACTR1 | 13 | 1.42 × 10−18 | 13 | 3.17 × 10−14 | 6 | 12717893 | 13288645 |
| PIP4K2C | 8 | 3.29 × 10−6 | 8 | 7.15 × 10−11 | 12 | 57984957 | 57997198 |
| PNKPa | 10 | 1.70 × 10−7 | 9 | 3.06 × 10−6 | 19 | 50364461 | 50371166 |
| POC5 | 36 | 3.50 × 10−6 | 24 | 2.98 × 10−142 | 5 | 74969949 | 75013313 |
| RBBP8 | 7 | 3.72 × 10−6 | 7 | 1.91 × 10−7 | 18 | 20378224 | 20606451 |
| RERE | 22 | 1.17 × 10−6 | 14 | 3.35 × 10−10 | 1 | 8412457 | 8877702 |
| RP11-724N1.1 | 12 | 2.16 × 10−6 | 9 | 2.64 × 10−15 | 10 | 104674342 | 104675161 |
| RP11-739L10.1 | 5 | 2.65 × 10−6 | 5 | 5.97 × 10−10 | 18 | 20279444 | 20513727 |
| RUFY2a | 26 | 8.24 × 10−6 | 16 | 1.75 × 10−21 | 10 | 70100864 | 70167051 |
| SFXN2 | 25 | 4.22 × 10−7 | 17 | 6.27 × 10−188 | 10 | 104474295 | 104503249 |
| STAT6 | 10 | 3.35 × 10−10 | 9 | 6.46 × 10−14 | 12 | 57489260 | 57525922 |
| TJP2 | 22 | 4.87 × 10−10 | 20 | 2.13 × 10−14 | 9 | 71736224 | 71870124 |
| TMEM194A | 16 | 8.45 × 10−9 | 16 | 6.51 × 10−10 | 12 | 57449426 | 57481846 |
| TUBG2a | 42 | 1.85 × 10−6 | 17 | 1.18 × 10−11 | 17 | 40811323 | 40819024 |
| UTP11L | 15 | 5.20 × 10−6 | 14 | 1.10 × 10−6 | 1 | 38474930 | 38490496 |
CHR, chromosome; MIN.TWAS.P, minimum p value from tissue-specific models; NUM.REF, number of tissue reference panels tested for each gene; NUM.REF.PRUNED, number of tissue reference panels tested for each gene after pruning for highly LD-correlated genes; OMNIBUS.P, p value from the omnibus test; P0, start of gene (hg19); P1, end of gene (hg19).
a
These gene are novel, with no prior reported GWAS SNP within 1 Mb.