Table 1.
Serum biomarkers of mice infected by C. neoformans and treated with miltefosine (MFS) or MFS-loaded alginate nanoparticles functionalized or not with polysorbate 80 (P80-MFS-AN and MFS-AN, respectively)
| Biomarkers | NINT | Untreated | MFS | MFS-AN | P80-MFS-AN |
|---|---|---|---|---|---|
| Urea (mg/dL) | 56.76 ± 7.77 | 49.84 ± 2.70 | 64.32 ± 18.56 | 49.76 ± 9.35 | 52.70 ± 9.66 |
| Creatinine (mg/dL) | 0.69 ± 0.08 | 0.68 ± 0.15 | 0.80 ± 0.06 | 0.78 ± 0.12 | 0.67 ± 0.09 |
| AST (U/L) | 268 ± 102.9 | 263.2 ± 249.7 | 265.8 ± 222.4 | 329.2 ± 283.8 | 197.2 ± 128.5 |
| ALT (U/L) | 49.50 ± 6.6 | 44.40 ± 18.62 | 52 ± 25.14 | 62.20 ± 23.44 | 43.20 ± 17.92 |
| ALP (U/L) | 518.4 ± 55.61 | 390.8 ± 83.79 | 361.6 ± 48.63 | 424.8 ± 114 | 375.2 ± 73.02 |
| Glucose (mg/dL) | 367.2 ± 94.28 | 258.8 ± 79.26 | 209.8 ± 52.96 | 271 ± 37.87 | 293.8 ± 32.15 |
| Triglycerides (mg/dL) | 211.4 ± 52.86 | 176 ± 19.52 | 208.3 ± 60.42 | 186.7 ± 44.83 | 194.7 ± 87.50 |
| Cholesterol (mg/dL) | 109.7 ± 8.57 | 106.6 ± 11.56 | 138.7 ± 47.13 | 121.6 ± 13.59 | 119.3 ± 6.43 |
All values are given as mean ± SD.