Table 2.

Association of COVID-19 Vaccination, Prior SARS-CoV-2 Infection, and Monoclonal Antibody Therapy With the Risk of Death Caused by the Delta or Omicron Variant

Variable	Delta Variant, HR (95% CI)	Omicron Variant, HR (95% CI)
Vaccination status
ȃUnvaccinated	Reference	Reference
ȃDose 2 ≥180 d	0.45 (.38–.54)	0.53 (.44–.64)
ȃDose 2 <180 d	0.45 (.30–.66)	0.26 (.14–.46)
ȃDose 3 ≥180 d	0.27 (.15–.49)	0.33 (.20–.55)
ȃDose 3 <180 d	0.43 (.29–.64)	0.28 (.22–.35)
ȃOther vaccination	0.92 (.70–1.21)	0.77 (.58–1.00)
Prior infection	0.22 (.08–.59)	0.47 (.30–.73)
Monoclonal antibodies	0.45 (.32–.62)	0.50 (.31–.79)
Age ≥65 y (vs <65 y)	8.57 (7.17–10.3)	9.92 (8.13–12.1)
Male (vs female)	1.51 (1.30–1.75)	1.41 (1.21–1.64)
Race and ethnicity
ȃWhite, non-Hispanic	Reference	Reference
ȃBlack, non-Hispanic	1.06 (.88–1.29)	1.13 (.94–1.36)
ȃHispanic	0.99 (.65–1.51)	0.94 (.62–1.41)
ȃOther/unknown	1.42 (1.07–1.89)	1.28 (.95–1.72)
Smoking status
ȃNever	Reference	Reference
ȃCurrent	1.20 (.91–1.57)	1.32 (1.03–1.70)
ȃUnknown	1.92 (1.63–2.26)	1.64 (1.38–1.94)
Respiratory conditions	0.97 (.83–1.14)	1.18 (1.00–1.39)
Nonrespiratory conditions	3.36 (2.61–4.32)	3.78 (2.77–5.17)
Immunocompromised conditions	4.18 (3.55–4.93)	4.56 (3.87–5.36)
Other location (vs Ohio)	0.64 (.42–.97)	0.52 (.39–.71)

Abbreviations: CI, confidence interval; HR, hazard ratio.