Table 1.
Clinical characteristics of patients with alcohol-associated hepatitis.
| Characteristic | Total (n = 432) |
|---|---|
| Anthropometric and history | |
| Age, years, median (IQR) | 48 (40–56) |
| Sex, female, n (%) | 157 (36.3%) |
| Sex, male, n (%) | 275 (63.7%) |
| Race, white, n (%) | 391 (90.5%) |
| BMI, kg/m2, median (IQR) | 27.9 (24.2–32.5) |
| History of AH, n (%) | 134 (31.1%) |
| History of AWS, n (%) | 116 (26.8%) |
| History of hepatic encephalopathy, n (%) | 91 (21.1%) |
| Corticosteroid use, n (%) | 192 (44.4%) |
| Data on Admission | |
| Creatinine (mg/dL), median (IQR) | 0.77 (0.6–1.2) |
| Na (mmol/L), median (IQR) | 133 (128–137) |
| Bilirubin (mg/dL), median (IQR) | 9.9 (6.3–19.1) |
| INR, median (IQR) | 1.7 (1.4–2.1) |
| Albumin (g/dL), median (IQR) | 2.6 (2.2–3) |
| Platelets (×109/L), median (IQR) | 114 (65–178) |
| MELD score, median (IQR) | 21.9 (18.3–27.3) |
| MELD score >20, n (%) | 277 (64%) |
| ABIC score, median (IQR) | 7.5 (6.6–8.8) |
| Complications | |
| AWS, n (%) | 140 (32.4%) |
| Gastrointestinal bleeding, n (%) | 72 (16.6%) |
| Ascites, n (%) | 267 (61.8%) |
| Infections, n (%) | 173 (40.1%) |
| AKI, n (%) | 140 (32.4%) |
| Encephalopathy, n (%) | 165 (38.2%) |
| Shock, n (%) | 34 (7.8%) |
| Need for intubation, n (%) | 58 (13.4%) |
| Clinical outcomes | |
| ICU admission, n (%) | 118 (27.3%) |
| Length of stay (days), median (IQR) | 11.0 (6.0–22.0) |
| ICU stay (days), median (IQR) | 5.0 (2.0–10.0) |
| Mortality on day 28, n (%) | 75 (17.3%) |
| Mortality on day 90, n (%) | 118 (27.3%) |
| Mortality on day 180, n (%) | 145 (33.6%) |
Abbreviations: ABIC, Age-bilirubin-INR-creatinine score; AH, Alcohol-associated hepatitis; AKI, Acute kidney injury; AWS, Alcohol withdrawal syndrome; BMI, Body mass index; ICU, Intensive care unit; INR, International ratio; IQR, Interquartile range; MELD, Model for end stage liver disease.