Figure 1.

The ARMADiLLO web server interface and results pages. (A) The ARMADiLLO web server provides a easy-to-use interface for antibody mutation probability analysis. To estimate mutation probabilities, users input an antibody sequence, specify the heavy or light chain type and choose a host species. ARMADiLLO results are then returned in two views: (B) a simple view comparing the amino acid sequences of the UCA and antibody sequence of interest with amino acid changes color-coded according to their estimated mutation probability and (C) a detailed view comparing both the amino acid and nucleotide sequences, highlighting AID hot and cold spots, and displaying the corresponding mutation probabilities associated with amino acid changes (see main text for detailed descriptions of the outputs).