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. 2023 May 11;51(W1):W310–W318. doi: 10.1093/nar/gkad407

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — (A) DIABLO result visualized in 3D scatter plot. (B) Statistical correlation results overlayed with model-based correlation heatmap. Features passed the threshold of adjusted P-value 0.1 were used in this analysis. The color gradients indicate the statistical correlations and asterisks show the statistically significant correlation filtered by raw P-value 0.05. Diamonds indicate the correlations were also predicted by the GEM-based prediction models. (C) Pathway enrichment results based on KOs and metabolites (yellow: tyrosine metabolism; green: vitamin B6 metabolism; blue: alanine, aspartate and glutamate metabolism). (D) Circle plot with a detailed table below showing the most related taxa for the selected metabolite, pyridoxamine. The result was obtained by clicking the corresponding node.