Figure 1.

A flowchart delineating process of model building and our data analysis protocol

TCGA, the cancer genome atlas; LUSC, lung squamous cell carcinoma; FPKM, Fragments Per Kilobase of exon model per Million mapped fragments; ESTIMATE, Estimation of STromal and Immune cells in MAlignant Tumors using Expression data; WGCNA, weighted gene co-expression network analysis; TME, tumor microenvironment; NSCLC, non-small cell lung cancer; LUAD, lung adenocarcinoma; TMB, tumor mutation burden; ssGSEA, single sample gene set enrichment analysis; TIDE, tumor immune dysfunction and exclusion; GDSC, Genomics of Drug Sensitivity in Cancer; CTRP, Cancer Therapeutics Response Portal; PD-L1, programmed cell death ligand 1; AUC, area under the receiver operating characteristic curve.