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. 2023 Jun 7;26(7):107058. doi: 10.1016/j.isci.2023.107058

Figure 6.

Figure 6

Validation of predictive value of TMErisk for chemotherapy in external cohorts

(A-B, E-F, I-J) Kaplan–Meier analyses for OS and PFS based on TMErisk strata in OAK cohorts (A-B, E-F) and POPLAR cohort (I-J). (C-D, G-H, K-L) Stacked percentage bar charts show the association of TMErisk with ORR and DCR in in OAK cohorts (C-D, G-H) and POPLAR cohort (K-L).

(M−N) Predictive accuracy of TMErisk, TMB and PD-L1 for OS (M) and PFS (N) in the POPLAR and IMvigor210 cohorts. HR, hazard ratio; CI, confidence interval; BOR, best overall response; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; ORR, objective response rate; DCR; OS, overall survival; PFS, progression-free survival; TMB, tumor mutation burden; PD-L1, programmed cell death ligand 1. See also Figures S10 and S12.