Table 1.
TP53 alteration frequencies in subgroups of AML and MDS
| Specific subgroup according to WHO 2017 | Number of cases | Cases without TP53 aberration [n] | Cases with TP53 aberration [n] | Frequency of TP53 aberration [%] | |
|---|---|---|---|---|---|
| AML | AML-MRC∗ | 152 | 87 | 65 | 43 |
| AML with t(9;11)(p21;q23); KMT2A::MLLT3 | 26 | 23 | 3 | 12 | |
| AML with inv(3)(q21q26); GATA2::MECOM | 32 | 29 | 3 | 9 | |
| Acute promyelocytic leukemia with PML::RARA | 50 | 46 | 4 | 8 | |
| Acute monoblastic and monocytic leukemia | 14 | 13 | 1 | 7 | |
| Therapy-related AML | 19 | 18 | 1 | 5 | |
| AML with maturation | 52 | 50 | 2 | 4 | |
| AML without maturation | 30 | 29 | 1 | 3 | |
| Acute myelomonocytic leukemia | 33 | 32 | 1 | 3 | |
| AML with mutated RUNX1 | 43 | 42 | 1 | 2 | |
| AML with mutated NPM1 | 160 | 158 | 2 | 1 | |
| AML with biallelic mutation of CEBPA | 47 | 47 | 0 | 0 | |
| AML with inv(16)(p13q22); CBFB::MYH11 | 47 | 47 | 0 | 0 | |
| AML with t(6;9)(p23;q34); DEK::NUP214 | 10 | 10 | 0 | 0 | |
| AML with minimal differentiation | 14 | 14 | 0 | 0 | |
| AML with t(8;21)(q22;q22); RUNX1::RUNX1T1 | 43 | 43 | 0 | 0 | |
| Total in AML | 772 | 688 | 84 | 11 | |
| MDS | Therapy-related MDS | 22 | 16 | 6 | 27 |
| MDS with isolated del(5q) (MDS 5q–)∗ | 104 | 83 | 21 | 20 | |
| MDS-EB-2∗ | 151 | 126 | 25 | 17 | |
| MDS-EB-1∗ | 149 | 128 | 21 | 14 | |
| MDS-RS-SLD | 42 | 38 | 4 | 10 | |
| MDS-RS-MLD∗ | 148 | 136 | 12 | 8 | |
| MDS-SLD | 18 | 17 | 1 | 6 | |
| MDS-MLD | 113 | 107 | 6 | 5 | |
| Total in MDS | 747 | 651 | 96 | 13 | |
| In total cohort | 1519 | 1339 | 180 | 12 |
AML and MDS subgroups are sorted according to frequency of TP53 alteration, respectively.
MDS-MLD, MDS with multilineage dysplasia; MDS-RS-MLD, MDS with multilineage dysplasia with ring sideroblasts; MDS-RS-SLD, MDS with single lineage dysplasia with ring sideroblasts; MDS-SLD, MDS with single lineage dysplasia.
∗
The subgroups in which more than 10 cases had TP53 alterations are highlighted in gray. Those were thus selected for further detailed analysis of the alteration type and OS.