Fig. 4.

RSTRs and LTBI subjects have distinct M.tb-specific adaptive immune profiles. (a) LASSO was applied to the full COMPASS and Luminex dataset for overlapping individuals to select a minimal set of features that best captured the variation between RSTR (n = 21) and LTBI (n = 9) subjects. Partial least squares discriminant analysis (PLS-DA) was then used to visualize the individuals in multivariate space captured by LASSO-selected parameters. Loadings plot indicates the relative contributions of each of the seven LASSO-selected features to the latent variable 1 (LV1, x-axis). (b) Correlation networks were developed between LASSO-selected features and all remaining features. All correlations were plotted with p value of <0.05 after Benjamini-Hochberg correction. T-cell measurements are shown with circles, and antibody measurements with triangles. Color of each feature represents relative enrichment in RSTRs (purple) versus LTBI (green). Positive correlations are shown with brown lines and negative correlations with blue lines.