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The formation of a Polymeric-Lipid Hybrid Nanoparticle. The Hybrid contains three distinct components which include: A polymeric core that encapsulates both hydrophilic and hydrophobic drugs effectively. A lipid shell that provides biocompatibility and high stability and a lipid-polyethylene glycol (PEG) that is found in the outer part and covered by a lipid layer to provide increased steric stability, prevent immune recognition and increase time for circulation.
