Table 1.
Four basic types of lipid-based drug-delivery systems (LBDDS) with their merits and demerits.
| Characteristics | SMEDDS | SNEDDS | SEDDS |
|---|---|---|---|
| Size of the globule | <250 nm | <100 nm | >300 nm |
| The system appearance | High Optical clarity | High Optical clarity | Cloudy |
| The surfactant HLB value | >12 | >12 | <12 |
| LFCS Classification | Type IIIB | Type IIIB | Type II |
| Oil phase | >20% | >20% | 40–80% |
| Surfactants Concentration | 40–80% | 40–80% | 30–40% |
HLB=Hydrophilic/lipophilic balance; LFCS = lipid formulation classification system; SEDDS = self-emulsifying drug-delivery systems; SMEDDS = self-microemulsifying drug-delivery systems; SNEDDS = self-nanoemulsifying drug-delivery system [70] (Rajpoot, Kuldeep 2020).