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. 2023 Jan 20;29(7):1024–1037. doi: 10.1093/ibd/izac281

Figure 2.

Figure 2.

Circulating lipid features associated with stricturing or internal penetrating Crohn’s disease (CD) patients vs control subjects. A and B, Volcano plots show all 715 and 1894 lipid features retained in the final dataset following analysis of serum samples of CD patients and healthy control subjects in IBDGC-1 and IBDGC-2, respectively. Colors indicate lipid subclasses: very long-chain dicarboxylic acid (VLCDCA), free fatty acid (FFA), acylcarnitine (AC), lysophosphatidylcholine (LPC), LPC ether (LPCO-), lysophosphatidylethanolamine (LPE), phosphatidylcholine (PC), PC ether (PCO-), phosphatidylethanolamine (PE), PE ether (PEO-), phosphatidylinositol (PI), sphingomyelin (SM), ceramide (Cer), glucosylceramide (GlcCer), cholesterol derivative (Chol der), sterol sulfate (ST sulf), cholesterol ester (CE), diglyceride (DG), and triglyceride (TG) species. Lipid identification is shown for the 15 most significant B2/B3-associated features annotated by tandem mass spectrometry in each dataset. C, The number of B2/B3-associated features annotated by lipid subclasses. FC, fold change; ND, nondetermined.