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. 2023 Jun 13;26(2):326. doi: 10.3892/ol.2023.13912

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Expression of LGALS1 in OC and its relationship with prognosis of patients. (A) GEO dataset standardization processing: (A-a) Before data processing and (A-b) after data processing. (B) Differential expression of LGALS1 mRNA in the tumor and control groups, and primary tumor and tumor metastasis groups was examined using the relevant GEO database datasets. Statistical analysis was performed using an unpaired t-test (GSE26712, GSE10971 and GSE12172) or paired t-test (GSE69428 and GSE30587). (C) Relationship between LGALS1 expression and different clinicopathological features. Association between the LGALS1 expression and (C-a) the age of patients, (C-b) histological grade, (C-c) the stage of OC, (C-d) lymphatic metastasis and (C-e) residual lesions. An unpaired t-test was used to compare the two groups. (D) Survival curves and subgroup analysis of overall survival in patients with OC, stratified by high and low expression of LGALS1 based on the best cutoff value. *P<0.05, **P<0.01. GEO, Gene Expression Omnibus; HGSOC, high-grade serous ovarian cancer; OSE, ovarian surface epithelium; FTE, fallopian tube epithelium; SO, serous ovarian; LMP, low malignant potential; SOC, serous ovarian cancer; HR, hazard ratio; LGALS1, galectin-1; OC, ovarian cancer; ns, not significant; TPM, transcripts per million.