Table 2.
Adverse events.
| AE | TVB-2640 + bevacizumab (any grade) | TVB-2640 + bevacizumab (grade 3–5) |
|---|---|---|
| PPE | 18 | 3 |
| Mucositis | 15 | 1 |
| HTN | 13 | 1 |
| Dry eye | 12 | 0 |
| Fatigue | 7 | 2 |
| Muscle weakness | 6 | 2 |
| Alopecia | 5 | 0 |
| Skin infection | 5 | 0 |
| Arthralgia | 4 | 0 |
| Myalgia | 4 | 0 |
| Elevated ALT | 3 | 1 |
| Allergic rhinitis | 3 | 0 |
| Elevated AST | 3 | 0 |
| Constipation | 3 | 0 |
| Depression | 3 | 0 |
| Dysphasia | 3 | 0 |
| Headache | 3 | 1 |
| Hoarseness | 3 | 0 |
| Paresthesia | 3 | 0 |
| Urinary tract infection | 3 | 1 |
| Back pain | 2 | 0 |
| Cognitive disturbance | 2 | 1 |
| Conjunctivitis | 2 | 0 |
| Diarrhea | 2 | 0 |
| Dry mouth | 2 | 0 |
| Dry skin | 2 | 0 |
| Limb edema | 2 | 0 |
| Hypokalemia | 2 | 1 |
| Pruritus | 2 | 0 |
| Seizure | 2 | 1 |
| Upper respiratory infection | 2 | 0 |
| Acute kidney injury | 1 | 0 |
| Anorexia | 1 | 0 |
| Anxiety | 1 | 0 |
| Aphasia | 1 | 0 |
| Bronchitis | 1 | 0 |
| Catheter-related infection | 1 | 1 |
| Confusion | 1 | 0 |
| Increased creatinine | 1 | 0 |
| Dysesthesia | 1 | 0 |
| Encephalitis | 1 | 1 |
| Conjunctival hemorrhage | 1 | 0 |
| Blepharitis | 1 | 0 |
| Fall | 1 | 0 |
| Flatulence | 1 | 0 |
| Gait disturbance | 1 | 0 |
| Gastritis | 1 | 1 |
| GERD | 1 | 0 |
| Hallucination | 1 | 1 |
| Hyperglycemia | 1 | 1 |
| Hypermagnesemia | 1 | 0 |
| Hypomagnesemia | 1 | 0 |
| Intracranial hemorrhage | 1 | 1 |
| Cerebrovascular ischemia | 1 | 0 |
| Optic neuritis | 1 | 1 |
| Thrombocytopenia | 1 | 0 |
| Proteinuria | 1 | 0 |
| Mood lability | 1 | 0 |
| Rash | 1 | 0 |
| Rectal hemorrhage | 1 | 0 |
| Perirectal pain | 1 | 0 |
| Scalp tenderness | 1 | 0 |
| Sepsis | 1 | 1 |
| Sinusitis | 1 | 0 |
| Candidiasis | 1 | 0 |
| Syncope | 1 | 1 |
| DVT | 1 | 1 |
| Urinary frequency | 1 | 0 |
| Urinary incontinence | 1 | 0 |
| Vomiting | 1 | 1 |
| Watering eyes | 1 | 0 |
| Weight loss | 1 | 0 |
| Perirectal abscess | 1 | 1 |
Abbreviation: HTN, hypertension.