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. 2023 Mar 30;22(7):833–843. doi: 10.1158/1535-7163.MCT-22-0537

Figure 2.

Figure 2. Inhibition of MET phosphorylation and downstream signaling molecules with tepotinib in EBC-1 lung cancer cells (A; ref. 30) and Hs746T gastric cells (B; ref. 33). A, Adapted with permission from Bladt F, et al. Clin Cancer Res 2013;19 (11):2941–51. AKT, protein kinase B; ERK, extracellular signal-regulated kinase; Gab1, Grb2-associated binder 1; MET, mesenchymal–epithelial transition factor.

Inhibition of MET phosphorylation and downstream signaling molecules with tepotinib in EBC-1 lung cancer cells (A; ref. 30) and Hs746T gastric cells (B; ref. 33). A, Adapted with permission from Bladt F, et al. Clin Cancer Res 2013;19 (11):2941–51. AKT, protein kinase B; ERK, extracellular signal-regulated kinase; Gab1, Grb2-associated binder 1; MET, mesenchymal–epithelial transition factor.