Figure 2.

ELL pyramidal cells display highly heterogeneous responses to envelope stimuli that are strongly attenuated by pharmacological inactivation of feedback pathways

(A) Simplified circuit diagram showing that pharmacological inactivation of feedback (pink arrow) onto ELL pyramidal cells was achieved by injecting lidocaine bilaterally into nP (red cross).

(B) Envelope stimulus waveform (top, green) and raster plots showing the activities of the same ELL pyramidal cell population before (middle, blue) and after (bottom, red) feedback inactivation in response to this stimulus. Overall, it is seen that responses were much more similar to one another after feedback inactivation.

(C) Histograms of the pairwise correlation coefficients between neural activities before (blue) and after (red) feedback inactivation. Note the increased probability of obtaining large correlation coefficient values near unity after feedback inactivation. Both distributions were significantly different from one another across our datasets (inset: two-sample Kolmogorov-Smirnov test, p = 1.04∗10⁻⁶, D = 39).