Figure 3.

Association of CTCF with differentially expressed genes in fed and starved livers

(A) Venn Diagram showing number of CTCF bound genes that overlap with genes induced in fed and 24 h starved mice liver (Fold Change (FC) ≥ 2, False Discovery Rate (FDR) ≤0.05).

(B) Distribution of genomic features in CTCF peaks overlapping with fed and starvation-induced genes.

(C and D) CTCF ChIP-seq signal intensities across genes hosting CTCF binding and are (C) feeding induced (558 genes) or (D) starvation-induced (275 genes) and clustered (k-mean) based on CTCF coverage profile (across gene body and 2Kb upstream and downstream of TSS and TTS, respectively).

(E and F) GO-BP terms enriched in genes associated with clusters generated in C (E) and D (F). UTR-Untranslated region, TSS-Transcription Start Site, TTS-Transcription Termination Site.