Table 1.

Results of genome-wide association study

Chr	Size of region (kb3)	Chromosomal Location (kb3)	Gene name(s)	Fatty Acid1	# of SNPs	P-value1	SNP1	Prior GWAS evidence2
1	4	248040	TRIM58, OR2W3	C18.1n9	3	4.63×10−18	rs3811444	(18)
2	23	27741	GCKR	C16.1n7	4	4.08×10−10	rs1260326	No
2	1 bp	196739	DNAH7	C17.0	1	5.51×10−10	rs72915157	No
3	23	142642	LOC100507389 ~PAQR9 ~PCOLCE2	C20.3n6	1	4.75×10−09	rs2608073	(18,19)
				C20.4n6	12	5.92×10−14	rs2608073
				C22.5n3	2	2.37×10−13	rs2608073
4	1 bp	111129	~ELOVL6	C18.0	1	4.26×10−09	rs5022521	No
5	1 bp	131357	~ACSL6	C22.5n3	1	4.59×10−09	rs61078674	No
6	167	11007	SYCP2L, ELOVL2, ELOVL2-AS1	C22.5n3	184	8.95×10−27	rs2236212	(18,19)
				C22.5n6	164	4.06×10−16	rs9368564
				C22.6n3	84	7.19×10−12	rs8523
	115	53165	ELOVL5, RPL31P28	C22.4n6	144	5.02×10−11	rs9474482
	90	135441	HBS1L	C22.4n6	49	1.79×10−23	rs9402685
	112	161643	AGPAT4	C22.4n6	20	3.07×10−20	rs75534358
10	121	102025	CHUK, BLOC1S2, PKD2L1	C18.1n7	5	3.28×10−23	rs603424	(19)
11	1 bp	58966	DTX4	C24.0	1	7.74×10−09	rs138458717	No
11	714	61512	SYT7,RPLP0P2, DAGLA, MYRF, TMEM258, FEN1, FADS2, FADS1, MIR1908, FADS3, RAB3IL1, BEST1, FTH1	C18.1n9	82	1.45×10−21	rs174551	(18,19)
				C18.2n6	305	7.96×10−112	rs174567
				C20.1n9	76	9.70×10−1/	rs174551
				C20.2n6	249	1.36×10−85	rs99780
				C20.3n6	580	1×10−256	rs174528
				C20.4n6	354	1.77×10−134	rs102275
				C20.5n3	79	3.31×10−18	rs12226877
				C22.4n6	157	1.58×10−33	rs174548
				C22.5n3	116	6.64×10−33	rs174546
				C22.5n6	53	9.49×10−16	rs61897793
12	202	7082	SPSB2, RPL13P5, LRRC23, ENO2, PTPN6, EMG1, PHB2, LPCAT3, C1S	C18.1n9	146	4.77×10−91	rs1984564	(18,19)
				C18.2n6	143	2.62×10−68	rs73266713
				C20.3n6	65	1.18×10−11	rs12579776
				C20.4n6	73	2.43×10−13	rs117633233
16	715	15481	PDXDC1, NTAN1, RRN3, NPIPP1, C16orf45, MYH11	C18.2n6	4	3.94×10−11	rs12928099	(19)
				C20.3n6	68	7.85×10−31	rs72789542
20	1 bp	33146	MAP1LC3A	C20.2n6	1	7.49×10−09	rs1040746	No

^1.Fatty acid, p-value and SNP are for the model showing the strongest evidence of association in the genomic region. Regions with significant associations for multiple fatty acids are depicted on separate rows.

^2.Identified in one of two prior RBC-FA genome-wide association studies.

^3.Kilobase (kb) is 1000s of base pairs (bp) and indicates the size of the region containing the significant SNPs or the number of kilobases from the end of the chromosome to the region of interest