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. 2023 Apr 26;4(4):276–293. doi: 10.1158/2643-3230.BCD-22-0205

Figure 1.

Figure 1. Overall response rate and measurable residual disease (MRD) clearance rates by multiparameter flow cytometry (MRD-MFC) and IDH1 digital-droplet PCR (ddPCR) in patients treated with IVO + VEN ± AZA. A, Overall response and composite complete response (CRc) rates across the study cohort. B, Timing of MRD-negative response in 10 patients obtaining MRD-MFC–negative CRc. 90% of patients attained MRD-MFC–negative remissions by 4 cycles of treatment. C, Clearance of IDH1 mutation in remission assessed using ddPCR in patients receiving <5 vs. ≥5 cycles of protocol-directed treatment. IDH1 mutation clearance was improved with continued cycles of therapy with IDH1 mutation clearance observed in 64% of patients receiving ≥5 cycles of treatment. IDH1 mutation clearance was observed across all disease types.

Overall response rate and measurable residual disease (MRD) clearance rates by multiparameter flow cytometry (MRD-MFC) and IDH1 digital-droplet PCR (ddPCR) in patients treated with IVO + VEN ± AZA. A, Overall response and composite complete response (CRc) rates across the study cohort. B, Timing of MRD-negative response in 10 patients obtaining MRD-MFC–negative CRc. 90% of patients attained MRD-MFC–negative remissions by 4 cycles of treatment. C, Clearance of IDH1 mutation in remission assessed using ddPCR in patients receiving <5 vs. ≥5 cycles of protocol-directed treatment. IDH1 mutation clearance was improved with continued cycles of therapy with IDH1 mutation clearance observed in 64% of patients receiving ≥5 cycles of treatment. IDH1 mutation clearance was observed across all disease types.