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. Author manuscript; available in PMC: 2023 Jul 5.
Published in final edited form as: Head Neck. 2021 Mar 4;43(7):1983–1994. doi: 10.1002/hed.26662

FIGURE 3.

FIGURE 3

Kaplan-Meier survival curves of TCGA database patients with oropharyngeal or laryngeal SCC, according to: (A,B) human epidermal growth factor receptor 2 (HER2) RNA expression and (C,D) HER2 protein expression. Overall survival (OS) is significantly improved in the upper tertian of HER2 RNA expression (“HER2 RNA+”) (p < 0.001). There is no difference in OS based on HER2 protein expression. For laryngeal SCC, there is better OS for the upper tertian of both HER2 RNA expression and protein expression (p = 0.327 and 0.004). (E) Based on a linear regression, HER2 RNA expression (ERBB2 RNA seq) and HER2 protein expression are only loosely correlated in head and neck squamous cell carcinoma from all three sites, with an R squared of 0.24