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CYLD regulates integral cellular activities including apoptosis and necrosis as well as the cell cycle. CYLD regulates critical cell death programs, apoptosis and necroptosis, through K63 deubiquitination of RIPK1. Additionally, CYLD has numerous regulatory roles throughout the cell cycle. These include deubiquitination of target proteins such as DVL and PLK1, as well as direct interactions with cell cycle effectors HDAC6 and CEP192. K63 Ub, K63-linked ubiquitin.
