Figure 1.

Immune-cell-specific transcriptomic signatures in the blood of control and COPD patients

(A) Sample collection and processing pipeline.

(B) Bar plot of absolute immune cell counts in the blood of 30 control and 56 COPD patients. Data are represented as the mean ± SD and statistical analysis was carried out with a Wilcoxon test, ^∗∗∗p < 0.001.

(C) Bar plot of immune cell proportions in the blood of 31 control and 69 COPD patients analyzed by flow cytometry. Data are represented as the mean ± SD and analysis was carried out with a two-tailed t test (neutrophils) or a Wilcoxon test (monocytes, eosinophils, T cells, B cells, NK cells) for non-normally distributed data, ^∗p < 0.05.

(D–F) Spearman correlation analysis of blood neutrophil counts with (D) percentage forced expiratory volume in 1 s (% FEV₁), (E) percentage emphysema in both lungs, and (F) FEV₁/FVC ratio. Color code depicts the stratification of COPD patients according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines.