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. 2023 Jul 5;22:104. doi: 10.1186/s12943-023-01806-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — The critical role of SLU7 in TNBC. (A) IB of SLU7 in MCF-10 A, MDA-MB-231, and MDA-MB-468. (B) IB of SLU7 in TNBC and normal tissue. (C) The correlation analysis between SLU7 and circCAPG in TNBC tissue. n = 132. (D) Cell proliferation assay of TNBC stable cell lines expressing control vector (Vector), SLU7 followed with infection of indicated control or circCAPG (OE-circCAPG). (scale bars, 1 cm). (E) Immunofluorescence with KI67 antibody in TNBC stable cell lines expressing control vector (Vector), SLU7 followed with infection of indicated control or circCAPG (scale bars, 50 μm). (F) Colony formation assay in TNBC stable cell lines expressing control vector (Vector), SLU7 followed with infection of indicated control or circCAPG. (scale bars, 1 cm) (G) IB of Cyclin D1 and CDK4 in TNBC stable cell lines expressing control vector (Vector), SLU7 followed with infection of indicated control or circCAPG. (H) Transwell assay of TNBC stable cell lines expressing control vector (Vector), SLU7 followed with infection of indicated control or circCAPG. (scale bars, 50 μm). (I) Wound healing assay of TNBC stable cell lines expressing control vector (Vector), SLU7 followed with infection of indicated control or circCAPG. (scale bars, 50 μm). (J) Image of TNBC patient-derived organoids infected with lentivirus expressing control or SLU7. All data were representative of at least three biological replicates and shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001