Table 1.

Classification of chiral antidepressant drugs

Class	Generic name	Brand name	Available as	More active form
SSRI	citalopram	Celexa, Cipramil, Zetalo, Lexapro	Racemate and (S)-citalopram	(S)-citalopram
	fluoxetine	Prozac, Sarafem, Rapiflux	Racemate and (S)-fluoxetine	(S)-fluoxetine
	sertraline	Zoloft, Actiser, Bioserene, Episod, Mentolift	Racemate and (+)-cis-(1S,4S)-sertraline	(+)-cis-(1S,4S)-sertraline
SNRI	paroxetine	Paxil, Brisdelle, Paxil CR, Pexeva	(−)-trans-(3S,4R)-paroxetine	(−)-trans-(3S,4R)-paroxetine
	venlafaxine	Effexor, Effexor XR	Racemate	(R)-venlafaxine
	duloxetine	Cymbalta, Drizalma Sprinkle, Irenka	(S)-duloxetine	(S)-duloxetine
	milnacipran	Ixel, Savella, Dalcipran, Toledomin	Mixture of d-milnacipran (1S,2R) and l-milnacipran (1R,2S)	d-milnacipran (1S,2R)
NRI	reboxetine	Edronax, Pfizer	Mixture of (S,R)-reboxetine, (R,R)-, (R,S)-reboxetine (S,S)-reboxetine	(S,S)-reboxetine
NDRI	bupropion	Wellbutrin, Zyban	Racemate	(R)-bupropion
MAOI	selegiline	Eldepryl, Zelapar	Racemate	(+)-selegiline
TeCA	mianserin	Bonserin, Tolvon, Athimil, Depnon, Deprexolet, Lantanon, Lerivon, Demisone, and others	Racemate	(S)-mianserin
NASSA	mirtazapine	Remeron, Mirataz, and others	Racemate	(S)-mirtazapine

MAOI, monoamine oxidase inhibitor; NASSA, noradrenergic and specific serotonergic antidepressant; NDRI, norepinephrine–dopamine reuptake inhibitor; NRI, norepinephrine (noradrenaline) reuptake inhibitor; SNRI, serotonin–norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TeCA, tetracyclic antidepressant.