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. 2023 Jun 4;19(10):2999–3014. doi: 10.7150/ijbs.83012

Figure 1.

Figure 1

SDPR inhibits tumour metastasis in vitro and vivo. (A) The differential expression of SDPR in gastric cancer and normal tissue using TCGA microarray analysis. (B) Western blot was used to verify the efficiency of SDPR overexpression and knockdown, respectively. (C) Transwell chamber migration assay was used to detect the migration and invasion abilities of MKN45 and MGC803 cells after SDPR overexpression or knockdown. The bar graph below shows the number of cells that have invaded. (D-E) The wound healing assay was used to detect the migration ability of MKN45 (D) and MGC803(E). The bars on the right represent migration indices. (F) Weight change curves of mice injected with SDPR-overexpressing and control cells. (G) Kaplan-Meier survival curves for mice injected with SDPR-overexpressing cells and control cells. P = 0.02. (H) Comparison of lung metastases in mice injected with overexpressing and control cells. ***P < 0.001; **** P < 0.0001. These experiments were repeated three times.