SDPR inhibits fatty acid oxidation. (A) Results of functional enrichment analysis of potential functions of SDPR by GO and KEGG databases. (B-C) FAO rate and ATP level of MKN45 and MGC803 cells after SDPR overexpression and knockdown. (D-E) FAO rate and ATP level of MKN45 and MGC803 cells treated with TGF-β for 0, 24, and 48h. (F-G) FAO rate and ATP level of MKN45 and MGC803 cells treated with TGF-β inhibitor (SB431542) for 0, 24, and 48h. (H-I) The recovery experiment showed the FAO rate and ATP level of MKN45 and MGC803 cells treated with TGF-β for 0, 24, or 48h and TGF-β 48h+ overexpression of SDPR. ** P < 0.01; *** P < 0.001; **** P < 0.0001. These experiments were repeated three times.