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. 2023 Jun 4;19(10):2999–3014. doi: 10.7150/ijbs.83012

Figure 4.

Figure 4

SDPR regulates CPT1A. (A) Heat map of overexpressed SDPR-related differential genes. (B-C) Western blot and qRT-PCR were used to detect the changes of CPT1A in MKN45 and MGC803 cells after SDPR overexpression and knockdown. (D) Gene function enrichment analysis of the GEO gastric cancer public database GSE57303 showed that CPT1A is associated with fatty acid metabolism. (E-F) Western blot and qRT-PCR were used to detect the changes of CPT1A in MKN45 and MGC803 cells treated with TGF-β for 0, 24, or 48h. (F-H) Western blot and qRT-PCR were used to detect the changes of CPT1A in MKN45 and MGC803 cells treated with TGFβ inhibitor (SB431542) for 0, 24, or 48h. ** P < 0.01; *** P < 0.001; **** P < 0.0001. These experiments were repeated three times.