TABLE 2.
Manifestation | Number of in-frame TM variants | Sample size (n) | Median | Lower quartile | Upper quartile |
---|---|---|---|---|---|
A | |||||
Diabetes Mellitus | NTM0 | 44 | 11 | 5 | 20 |
Diabetes Mellitus | NTM1 | 23 | 9 | 7.5 | 11 |
Diabetes Mellitus | NTM2 | 42 | 6 | 4 | 8 |
Optic Atrophy | NTM0 | 41 | 15.3 | 9 | 25 |
Optic Atrophy | NTM1 | 19 | 10 | 9.5 | 19.5 |
Optic Atrophy | NTM2 | 37 | 9 | 8 | 13 |
Diabetes Insipidus | NTM0 | 16 | 14 | 10.75 | 17.2775 |
Diabetes Insipidus | NTM1 | 6 | 11.5 | 9.5 | 14.25 |
Diabetes Insipidus | NTM2 | 24 | 15.3 | 10 | 24 |
Hearing Loss | NTM0 | 20 | 16 | 9.275 | 25.25 |
Hearing Loss | NTM1 | 8 | 8.5 | 5 | 14.25 |
Hearing Loss | NTM2 | 31 | 12 | 8.5 | 15 |
Manifestation | Comparison | p-value | Adjusted p-value |
---|---|---|---|
B | |||
Diabetes Mellitus | NTM0-NTM2 | 1.20E-03 | 1.44E-02 |
Diabetes Mellitus | NTM0-NTM1 | 3.52E-01 | 1.00E+00 |
Diabetes Mellitus | NTM1-NTM2 | 1.26E-04 | 1.51E-03 |
Optic Atrophy | NTM0-NTM2 | 1.54E-03 | 1.85E-02 |
Optic Atrophy | NTM0-NTM1 | 2.33E-01 | 1.00E+00 |
Optic Atrophy | NTM1-NTM2 | 7.90E-02 | 9.48E-01 |
Diabetes Insipidus | NTM0-NTM2 | 7.40E-01 | 1.00E+00 |
Diabetes Insipidus | NTM0-NTM1 | 2.69E-01 | 1.00E+00 |
Diabetes Insipidus | NTM1-NTM2 | 1.78E-01 | 1.00E+00 |
Hearing Loss | NTM0-NTM2 | 2.03E-01 | 1.00E+00 |
Hearing Loss | NTM0-NTM1 | 1.54E-01 | 1.00E+00 |
Hearing Loss | NTM1-NTM2 | 2.44E-01 | 1.00E+00 |
Manifestation | Number of in-frame TM variants | Sample size (n) | Median | Lower quartile | Upper quartile |
---|---|---|---|---|---|
C | |||||
Diabetes Mellitus | NTM0 | 51 | 8 | 6 | 10.4 |
Diabetes Mellitus | NTM1 | 36 | 4.7 | 3.5 | 7 |
Optic Atrophy | NTM0 | 52 | 13 | 9.75 | 16.25 |
Optic Atrophy | NTM1 | 35 | 10 | 8 | 16 |
Diabetes Insipidus | NTM0 | 20 | 12 | 11 | 14 |
Diabetes Insipidus | NTM1 | 18 | 9.75 | 6.25 | 19.5 |
Hearing Loss | NTM0 | 21 | 14 | 13 | 18 |
Hearing Loss | NTM1 | 27 | 12 | 8.055 | 18 |
Manifestation | Comparison | p-value | Adjusted p-value |
---|---|---|---|
D | |||
Diabetes Mellitus | NTM0-NTM1 | 4.33E-05 | 1.73E-04 |
Optic Atrophy | NTM0-NTM1 | 7.32E-02 | 2.93E-01 |
Diabetes Insipidus | NTM0-NTM1 | 4.38E-01 | 1.00E+00 |
Hearing Loss | NTM0-NTM1 | 2.40E-01 | 9.61E-01 |