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. 2023 Jun 21;14:1198171. doi: 10.3389/fgene.2023.1198171

TABLE 2.

Age of onset and Wilcoxon Rank Sums test results for number of transmembrane in-frame variants analysis. A) Sample size, median, and quartile age of onset information for each clinical manifestation for different numbers of transmembrane in-frame variants in patients who have two in-frame variants. (B) Wilcoxon Rank Sums test p-values and Bonferonni adjusted p-values for pairwise comparisons among numbers of transmembrane in-frame variants in patients who have two in-frame variants. I Sample size, median, and quartile age of onset information for each clinical manifestation for different numbers of transmembrane in-frame variants in patients who have one in-frame variant. (D) Wilcoxon Rank Sums test p-values and Bonferonni adjusted p-values for pairwise comparisons among numbers of transmembrane in-frame variants in patients who have one in-frame variant. NTM0: zero transmembrane in-frame variants. NTM1: one transmembrane in-frame variant. NTM2: two transmembrane in-frame variants.

Manifestation Number of in-frame TM variants Sample size (n) Median Lower quartile Upper quartile
A
Diabetes Mellitus NTM0 44 11 5 20
Diabetes Mellitus NTM1 23 9 7.5 11
Diabetes Mellitus NTM2 42 6 4 8
Optic Atrophy NTM0 41 15.3 9 25
Optic Atrophy NTM1 19 10 9.5 19.5
Optic Atrophy NTM2 37 9 8 13
Diabetes Insipidus NTM0 16 14 10.75 17.2775
Diabetes Insipidus NTM1 6 11.5 9.5 14.25
Diabetes Insipidus NTM2 24 15.3 10 24
Hearing Loss NTM0 20 16 9.275 25.25
Hearing Loss NTM1 8 8.5 5 14.25
Hearing Loss NTM2 31 12 8.5 15
Manifestation Comparison p-value Adjusted p-value
B
Diabetes Mellitus NTM0-NTM2 1.20E-03 1.44E-02
Diabetes Mellitus NTM0-NTM1 3.52E-01 1.00E+00
Diabetes Mellitus NTM1-NTM2 1.26E-04 1.51E-03
Optic Atrophy NTM0-NTM2 1.54E-03 1.85E-02
Optic Atrophy NTM0-NTM1 2.33E-01 1.00E+00
Optic Atrophy NTM1-NTM2 7.90E-02 9.48E-01
Diabetes Insipidus NTM0-NTM2 7.40E-01 1.00E+00
Diabetes Insipidus NTM0-NTM1 2.69E-01 1.00E+00
Diabetes Insipidus NTM1-NTM2 1.78E-01 1.00E+00
Hearing Loss NTM0-NTM2 2.03E-01 1.00E+00
Hearing Loss NTM0-NTM1 1.54E-01 1.00E+00
Hearing Loss NTM1-NTM2 2.44E-01 1.00E+00
Manifestation Number of in-frame TM variants Sample size (n) Median Lower quartile Upper quartile
C
Diabetes Mellitus NTM0 51 8 6 10.4
Diabetes Mellitus NTM1 36 4.7 3.5 7
Optic Atrophy NTM0 52 13 9.75 16.25
Optic Atrophy NTM1 35 10 8 16
Diabetes Insipidus NTM0 20 12 11 14
Diabetes Insipidus NTM1 18 9.75 6.25 19.5
Hearing Loss NTM0 21 14 13 18
Hearing Loss NTM1 27 12 8.055 18
Manifestation Comparison p-value Adjusted p-value
D
Diabetes Mellitus NTM0-NTM1 4.33E-05 1.73E-04
Optic Atrophy NTM0-NTM1 7.32E-02 2.93E-01
Diabetes Insipidus NTM0-NTM1 4.38E-01 1.00E+00
Hearing Loss NTM0-NTM1 2.40E-01 9.61E-01