Table 1.
Distribution of synucleinopathy by Braak Lewy body stage and basic demographics
| Lewy body stage* (no. of patients) |
Age at onset of motor symptoms (yr) mean±SD |
Age at onset of dementia (yr) mean±SD |
Duration of motor symptoms (yr) mean±SD |
Age at death (yr) mean±SD |
|---|---|---|---|---|
| PDND (37) | 56.6 ± 14.6† | - | 17.0 ± 9.7 | 73.4 ± 11.5† |
| Braak 3 (5) | 62.5 ± 11.1 | - | 12.1 ± 5.8 | 74.6 ± 6.7 |
| Braak 4 (7) | 63.9 ± 13.9 | - | 13.7 ± 9.8 | 77.6 ± 9.0 |
| Braak 5 (15) | 56.1 ± 12.9 | - | 19.0 ± 10.6 | 75.1 ± 8.8 |
| Braak 6 (10) | 49.4 ± 17.1 | - | 18.7 ± 9.7 | 68.0 ± 16.9 |
| PDD (114) | 62.4 ± 9.6 | 74.1 ± 6.8‡ | 16.4 ± 6.5‡ | 78.8 ± 6.0‡ |
| Braak 3 (1) | 56 | 73 | 19 | 75 |
| Braak 4 (6) | 60.1 ± 1.6 | 72.5 ± 7.0 | 16.1 ± 7.3 | 76.2 ± 6.1 |
| Braak 5 (34) | 62.0 ± 11.0 | 73.1 ± 7.7 | 16.1 ± 7.3 | 77.9 ± 6.1 |
| Braak 6 (73) | 63.0 ± 9.4 | 74.7 ± 6.4 | 16.5 ± 6.4 | 79.5 ± 5.9 |
| DLB (14) | 64.1 ± 8.5 | 64.9 ± 8.3 | 10.1 ± 4.1 | 74.2 ± 6.5 |
| Braak 3 (1) | 64 | 64 | 4 | 68 |
| Braak 4 (1) | 68 | 68 | 11 | 79 |
| Braak 5 (6) | 61.9 ± 11.8 | 63.8 ± 11.7 | 12.4 ± 3.9 | 74.3 ± 9.3 |
| Braak 6 (6) | 65.6 ± 6.0 | 65.7 ± 6.3 | 8.6 ± 3.6 | 74.2 ± 3.7 |
*
Lewy body stage according to Braak H, Del Tredici K, Rub U et al. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 2003; 24:197–211
†
indicates significant difference (prior to correction for multiple comparisons) between PDND and combined dementia group, p < 0.05
‡
indicates significant difference between PDD and DLB, p < 0.05