Table 2.

A. Logistic regression model predicting diagnosis of dementia. For each pathological predictor, omnibus significance (via Wald χ²) is followed by odds ratios and significance for each predictor level. B. Supplemental model analyzing NIA-AA pathological categories comprising ADNC score as predictors of dementia.

A.
Pathology		Odds Ratio (95% CI)	Wald χ2	Significance
Lewy Body (Braak)				0.002*
	Braak 4a	1.68 (0.16 – 18.08)		0.670
	Braak 5a	7.46 (0.80 – 69.49)		0.078
	Braak 6a	35.18 (3.21 – 385.64)		0.004*
ADNC				0.818
	Lowb	1.33 (0.46 – 3.89)		0.601
	Intermediateb	2.34 (0.42 – 13.11)		0.335
	Highb	†		0.999
CAA				0.427
	Minimalb	0.35 (0.02 – 6.48)		0.478
	Mildb	0.51 (0.15 – 1.72)		0.280
	Moderateb	0.11 (0.01 – 1.10)		0.061
	Severeb	0.47 (0.03 – 7.32)		0.590
Arteriolosclerosis				0.436
	Mildb	2.67 (0.14 – 52.01)		0.518
	Moderateb	1.83 (0.09 – 36.77)		0.694
	Severeb	13.11 (0.30 – 575.3)		0.182
B.
Pathology		Odds Ratio (95% CI)	Wald χ2	Significance
β-amyloid			2.257	0.521
	Score 1c	2.64 (0.731 – 9.51)	2.196	0.138
	Score 2c	1.37 (0.33 – 5.67)	0.192	0.662
	Score 3c	1.53 (0.13 – 17.44)	0.116	0.733
NFT			0.852	0.837
	Score 1c	0.39 (0.045 – 3.34)	0.746	0.388
	Score 2c	0.56 (0.043 – 7.36)	0.194	0.659
	Score 3c	†	3.0 x 10−6	0.999
Neuritic plaques			1.711	0.634
	Score 1c	6.80 (0.39 – 120.1)	1.711	0.191
	Score 2c	†	4.0 x 10−6	0.998
	Score 3c	†	1.65 x 10−10	0.999

ADNC = Alzheimer disease neuropathologic change, CAA = Cerebral amyloid angiopathy, NFT = neurofibrillary tangles

^*denotes significance at p = 0.05.

^†Odds ratio with 95% CI could not be calculated.

^aContrast with Braak stage 3.

^bContrast with “none”.

^cContrast with score 0.