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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Ann Neurol. 2022 Nov 22;93(1):184–195. doi: 10.1002/ana.26542

Table 5.

TDP-43 positivity, ARTAG and AGD in Parkinson patients categorized by dementia status and stratified by Braak Lewy body stage*

Lewy body stage TDP-43 positivity
No. of cases
(total assessed)
ARTAG
No. of cases
(total assessed)
AGD
No. of cases
(total assessed)
PDND
  Braak 3 0 (4) 0 (1) 0 (5)
  Braak 4 0 (4) 0 (3) 0 (7)
  Braak 5 0 (13) 1 (7) 1 (15)
  Braak 6 1 (8) 1 (4) 2 (10)
 
PDD
  Braak 3 0 (1) 0 (1) 0 (1)
  Braak 4 0 (6) 3 (5) 1 (6)
  Braak 5 2 (32) 10 (19) 1 (34)
  Braak 6 17 (58) 7 (18) 7 (73)
 
DLB
  Braak 3 0 (1) 0 (1) 0 (1)
  Braak 4 0 (1) 0 (1) 0 (1)
  Braak 5 1 (4) 0 (1) 0 (6)
  Braak 6 1 (5) 1 (2) 0 (6)
*

Lewy body stage according to Braak H, Del Tredici K, Rub U et al. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 2003; 24:197–211

TDP-43: TAR DNA-binding protein immunoreactive neuronal cytoplasmic inclusions

ARTAG: age-related tau astrogliopathy

AGD: argyrophilic grain disease

PDND: Parkinson disease without dementia

PDD: Parkinson disease with dementia

DLB: dementia with Lewy bodies