TABLE 3.
Univariate and Multivariate Cox Regression Analyses for DFS and OS of MBC
| Clinicopathological features | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|---|---|
| DFS HR (95% CI) |
P | DFS HR (95% CI) |
P | OS HR (95% CI) |
P | OS HR (95% CI) |
P | |
| Age (<40 vs ≥40) |
2.962 (0.191–4.873) |
0.116 | — | — | 2.692 (2.256–2.056) |
0.326 | — | — |
| Tumor size (≤2 cm vs >2 cm) |
2.687 (1.399–3.825) |
0.006 | 3.625 (2.753–6.569) |
0.005 | 3.332 (1.325–4.628) |
0.012 | 3.677 (1.849–3.602) |
0.010 |
| Lymph node status (absent vs present) |
3.923 (1.921–3.245) |
0.021 | 3.874 (1.951–3.532) |
0.023 | 3.093 (1.561–3.243) |
0.035 | 3.608 (1.876–3.894) |
0.023 |
| TNM stage (I vs II, III) |
2.209 (1.281–5.238) |
0.008 | 3.351 (1.046–5.624) |
0.012 | 2.033 (1.088–6.875) |
0.032 | 3.023 (1.408–4.929) |
0.004 |
| CD4 (low vs. high) |
2.945 (0.261–3.292) |
0.874 | — | — | 3.201 (1.931–4.345) |
0.748 | — | — |
| CD8 (low vs high) |
3.355 (1.826–3.345) |
0.012 | 3.252 (1.092–3.662) |
0.001 | 2.784 (1.976–3.930) |
0.008 | 2.406 (2.943–3.965) |
0.001 |
| FoxP3 (low vs high) |
3.298 (1.874–3.234) |
<0.001 | 2.945 (1.824–3.243) |
0.001 | 3.452 (1.051–3.076) |
0.001 | 3.732 (1.941–3.025) |
0.012 |
| CD8/FoxP3 (low vs high) |
3.626 (1.245–3.234) |
0.063 | 3.925 (1.252–6.023) |
0.023 | 3.836 (1.832–3.895) |
0.013 | 3.670 (1.943–3.686) |
0.020 |
DFS indicates disease-free survival; HR, hazard ratio; MBC, medullary breast carcinoma; OS, overall survival.