TABLE 4.
Univariate and Multivariate Cox Regression Analyses for DFS and OS of High-grade TNBC Without Medullary Pattern
| Clinicopathological features | DFS Univariate analysis |
Multivariate analysis | OS Univariate analysis |
Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|---|
|
HR (95% CI) |
P |
HR (95% CI) |
P |
HR (95% CI) |
P |
HR (95% CI) |
P | |
| Age (<40 vs ≥40) |
1.769 (0.851–3.567) |
0.026 | 2.353 (0.516–2.749) |
0.014 | 1.802 (1.756–3.261) |
0.002 | 2.283 (1.851–5.015) |
0.012 |
| Tumor size (≤2 cm vs >2 cm) |
3.387 (1.809–3.536) |
0.025 | 3.653 (2.729–4.749) |
0.012 | 3.623 (1.321–4.656) |
0.022 | 3.651 (1.511–3.661) |
0.008 |
| Lymph node status (absent vs present) |
3.603 (1.821–3.985) |
0.031 | 3.427 (1.031–3.605) |
0.002 | 2.934 (1.934–3.262) |
0.020 | 3.053 (2.351–4.545) |
0.001 |
| TNM stage (I vs II, III) |
2.863 (1.488–7.225) |
0.005 | 2.753 (1.093–5.765) |
0.004 | 3.019 (1.150–6.854) |
0.002 | 2.726 (1.601–4.935) |
0.002 |
| CD4 (low vs high) |
2.469 (0.851–3.567) |
0.198 | 2.233 (1.854–3.651) |
0.103 | ||||
| CD8 (low vs high) |
2.387 (1.809–3.536) |
0.005 | 2.952 (1.042–3.952) |
0.004 | 2.515 (1.951–4.515) |
0.010 | 2.606 (2.723–3.032) |
0.002 |
| FoxP3 (low vs high) |
3.603 (1.821–3.985) |
0.025 | 3.495 (1.752–4.963) |
0.022 | 3.512 (3.011–3.025) |
0.005 | 3.984 (1.961–3.051) |
0.012 |
| CD8/FoxP3 (low vs high) |
3.603 (1.821–3.985) |
0.002 | 3.954 (1.731–3.017) |
0.010 | 3.345 (1.025–3.571) |
0.001 | 3.150 (2.613–5.618) |
0.002 |
DFS indicates disease-free survival; HR, hazard ratio; OS, overall survival; TNBC, triple-negative breast cancer.