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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Adv Biol (Weinh). 2022 Jun 1;6(8):e2101313. doi: 10.1002/adbi.202101313

Extended Data Figure 3. 16S profile changes over the first week after birth in LP and VLBW infants.

Extended Data Figure 3.

Within-infant 16S Robust Aitchison distance to first sample over time. For each infant, the Robust Aitchison distance to the first sample (day 0 for LPI infants, day 1 for VLBW infants) is plotted over time for each body site. Red lines show the fitted linear mixed effects model (individual as a random effect and age as a fixed effect); the corresponding p-value and slope is shown. All body sites show a trend of increasing distance over time, indicating that microbial profiles change over the first week after birth. Boxplots show median and interquartile range with whiskers extending to the furthest value within 1.5 times the edge of the interquartile range. Refer to Extended Data Table 3 for sample sizes in each comparison.